Description
Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed: 26902720). Required for normal embryonic mesoderm development and formation of caudal somites (PubMed: 8299937). Required for normal morphogenesis of the developing neural tube (PubMed: 8299937). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed: 26902720)